| ncRNA name | PEDF siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human RPE cell line ARPE-19 |
| Methods | siRNA transfection, luciferase reporter assay, RT-PCR, confocal microscopy, ELISA, Western blot, immunoprecipitation, immunoblot |
| Expression pattern | associated |
| Functional description | Wnt signaling is known to regulate multiple processes including angiogenesis, inflammation, and fibrosis. PEDF knockdown by siRNA and PEDF knockout in PEDF(-/-) mice induced activation of Wnt signaling. |
| PubMed ID | 21576363 |
| Year | 2011 |
| Title | Identification of a novel inhibitor of the canonical Wnt pathway. |
| Drug-related ncRNA | NO |
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